Micky van de Ven Double Halts Everton's Run at Brand New Home Ground
The Dutch defender became the initial defender to score twice in a English top-flight match for Tottenham since the Belgian defender in March 2013.
At a glance
Micky Van de Ven heads into the net two times in first half
Everton's Jake O'Brien has equalizer disallowed after VAR review
Pape Matar Sarr scores final goal in dying moments
The defeat is Everton's first at their new ground
Micky van de Ven scored twice as Tottenham extended their winning streak on the road in the top division and delivered the Toffees their first defeat at Hill Dickinson Stadium.
Everton were undefeated in their last five matches at their recently opened stadium at the dockside location, having left Goodison Park behind after 133 years at the end of last season.
But Tottenham's leader Van de Ven struck on two occasions from set-pieces in the opening 45 minutes to put their impressive record at risk, and they were unable to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - nodded in a third to put the game to bed.
The Everton defender thought he had levelled the tally five minutes after Van de Ven's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, missed a number of chances, while Vicario made a series of excellent stops to guarantee Tottenham went five matches on the road unbeaten in the English top flight.
But the VAR intervened, advising the match official to review the score on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's team up to third in the Premier League, a handful of points off local foes and leaders Arsenal.
Everton remain in 14th position and sit six points clear of the drop zone.
Spurs breakdown: The defender excels in duties at both ends of pitch
Following a drab midweek performance in the Champions League against Monaco, where they mustered a mere attempts on goal, the manager opted for Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The summer signing was failed to influence the game before being replaced for the substitute after an hour on the pitch, but it emerged he proved unnecessary in the final outcome.
Centre-back the Dutchman transformed into an offensive threat to be feared.
Tottenham's opening strike came from a cleverly executed corner routine, with the midfielder heading the ball back across the face of goal for an unmarked the defender to score.
And the captain - stepping up as skipper in Cristian Romero's unavailability - added his next goal in first-half stoppage time as he outjumped the England keeper to nod in.
The Dutchman was just as outstanding in defence, partnering well with Kevin Danso as the duo handled superbly with the numerous deliveries thrown their way by Everton.
Everton analysis: Toffees missing striker's instinct
Everton's new home had been a happy hunting ground, but it appears the novelty may have worn off slightly and fans flocked to the gates after the midfielder's third for Tottenham.
The break in the team's unbeaten home run will not be a massive concern for David Moyes, but their attacking woes are.
Beto and Thierno Barry - the Everton's two established centre-forwards - had scored just one league goal combined before the weekend's match.
And they were failed to add to that miserable record on a wet and gloomy evening on Merseyside.
The striker's performance was summed up when he chose to overhead kick a clear chance from close range, despite having room and time to readjust for a simpler shot that would have tested the keeper.
Barry, too, failed to influence the game after coming on for Beto in the 65th minute.
It was not for a shortage of chance. Most of the home side's attacks came through Grealish and the forward, who tirelessly whipped dangerous balls into the Spurs box.
What next for these two sides?
The Toffees: Moyes' men head to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Spurs: The London club travel to St James' Park on Wednesday, 29 October for their fourth-round League Cup match against the Magpies.